Martin Wabitsch

This study compares FLASH and conventional radiotherapy effects on white adipose tissue, finding FLASH better preserves tissue function and structure while conventional RT causes metabolic and inflammatory changes.

This study identifies 282 genetic loci associated with insulin resistance through multi-trait GWAS, highlighting adipose-specific and systemic regulators and potential therapeutic targets.

Inhibition of AKR1C3 reduces 11-oxygenated androgens but not classic androgens in women.

The paper identifies 1,580 cell type-specific genes and non-coding RNAs associated with coronary artery disease by integrating genetic and epigenetic data from multiple cell types.

This study investigates the role of PPAR-delta versus PPAR-gamma in modulating central carbon metabolism during adipogenesis in human adipocytes using real-time qPCR and metabolic arrays.

This study evaluates the lipolytic and anti-adipogenic effects of capsaicin, camphor, and caffeic acid on human SGBS adipocytes, showing reduced lipid accumulation and increased lipolysis, with capsaicin having the strongest effects.

This study shows that FFA4 inverse agonism affects adipogenesis and adipocyte function, with AH7614 suppressing adipogenesis and enhancing lipolysis.

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

This study creates a spatiotemporal proteomic map of human adipogenesis, revealing changes in protein abundance, localization, and metabolic pathway reprogramming during adipocyte differentiation.

The paper identifies key driver genes affecting adipocyte function and body fat distribution using systems genetics and experimental validation.

The paper estimates the prevalence of putatively pathogenic leptin variants in the gnomAD database, finding low frequencies with higher risk in South Asian populations.

CROP-Seq uses CRISPRi and scRNA-Seq to screen gene targets in adipocytes, identifying gene knock-down effects and novel regulators of adipogenesis and metabolic disease.

The paper integrates genetic colocalizations with physiological and pharmacological perturbations to identify causal genes for cardiometabolic diseases.

The paper identifies environmental modulators of genetic risk factors for complex traits by integrating perturbation data with GWAS.

This study identifies AATBC as a human-specific lncRNA that regulates adipocyte plasticity and mitochondrial function, linking it to metabolic health.

This study identifies HAND2 as an obesity-linked adipogenic transcription factor regulated by glucocorticoids, showing its role in adipocyte differentiation and its correlation with BMI in humans.