Montgomery Blencowe

This study identifies magnolol and dicoumarol as natural compounds that enhance adipogenesis in multiple cell systems, offering potential for food applications and tissue engineering.

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

This study shows that reducing Glo1 in mice causes age- and sex-dependent metabolic issues like obesity and altered lipid metabolism without significant changes in AGEs.

This study identifies shared and distinct genetic pathways between human and mouse in coronary artery disease using multi-omics data and GWAS, showing over 75% shared pathways.

This study investigates the genetic basis of dietary iron overload and associated pathologies in mice using the Hybrid Mouse Diversity Panel, identifying genetic loci and pathways involved.

This study identifies 17 genetic risk loci for spontaneous coronary artery dissection (SCAD), including 12 new ones, and highlights genes related to artery integrity and coagulation.

CROP-Seq uses CRISPRi and scRNA-Seq to screen gene targets in adipocytes, identifying gene knock-down effects and novel regulators of adipogenesis and metabolic disease.

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

PharmOmics predicts drug repurposing by analyzing species- and tissue-specific drug signatures from genomic data and validates predictions in mice.

This study identifies gene networks and pathways associated with plasma lipid traits using multi-tissue multi-omics analysis, revealing both known and novel regulators of lipid metabolism.

This study shows DHA has different effects on rat brain gene expression, pathways, and metabolic outcomes depending on dietary context.

This study examines how fructose affects metabolic and transcriptomic responses in genetically diverse mice, identifying strain-specific pathways and regulators involved in metabolic dysfunctions.