Daniel Jirák

The paper identifies de novo EHMT2 variants causing an autosomal dominant Kleefstra syndrome by impairing G9a methyltransferase activity, mimicking EHMT1 haploinsufficiency.

This paper introduces a system for functionalizing extracellular vesicles with nanobody adapters, enabling flexible and efficient attachment of target proteins without genetic engineering of cells.

This study shows that long-term PI3Kδ overexpression in adult rat cortex using AAV1 is safe and well-tolerated, with no adverse effects observed over one year.

This study identifies plectin as a critical mediator of mechanical homeostasis in hepatocellular carcinoma, showing that its inhibition suppresses tumor growth and metastasis.

This study maps the spatiotemporal transcriptomic changes in mouse brain tissue after ischemic injury, revealing glial cell responses and their role in neuroinflammation.

This study shows that plectin is essential for intestinal epithelial integrity and protects against colitis by maintaining mechanical stability and junctional function.