Long-Term Expression and Safety of AAV1-Mediated PI3Kδ Overexpression in the Adult Rat Cortex
L. W. Knight, Polcanova Zuzana, Dana Mareková, Lucia Machová Urdzíková, Daniel Jirák, Natalia Ziółkowska, Pavol Makovicky, Fred de Winter, Jessica C. F. Kwok, Pavla Jendelová, James W. Fawcett, Kristýna Kárová
This study shows that long-term PI3Kδ overexpression in adult rat cortex using AAV1 is safe and well-tolerated, with no adverse effects observed over one year.
bioRxiv · Jan 23, 2026 · PreprintNeuroscience