Marina Naval-Sánchez

The paper develops a scalable MNase-seq workflow for reproducible nucleosome profiling across multiple cell types and models.

This study shows that c-Src is essential for neovascular tuft formation in Oxygen-Induced Retinopathy, as its depletion reduces tuft formation without affecting cell death, proliferation, or adhesion.

This study introduces UnTANGLeD, an unsupervised method that organizes genes into programs based on gene-trait associations, revealing 173 clusters with distinct biological functions and disease relevance.

The paper uses micrococcal nuclease sequencing on porcine sperm to identify nucleosomal fractions and links them to semen quality and early embryo development.

The paper identifies POLYCERATE alleles in sheep and goats linked to defective HOXD1 function, showing haploinsufficiency causes horn bud splitting and highlights HOXD1's role in headgear patterning in Bovidae.

The paper introduces a method to analyze genome-wide co-expression distributions to identify genes with functional importance by comparing distribution shapes across species.

The paper identifies regulators of sexual maturation in Atlantic salmon by integrating transcriptome, methylome, and chromatin accessibility data from a time course experiment.

This paper develops a statistical model to detect buffering loci in genome-wide association studies and identifies loci with significant epistatic effects but no additive effects in bovine data.

The paper identifies NR2F6 and TGFB1 as key regulators of feed efficiency in beef cattle using systems biology approaches and validates their roles in hepatic inflammation and muscle development.

The paper develops a computational method to predict regulatory regions in mammals using human genomics data, and applies it to cattle to prioritize variants and identify genome editing targets.