Osvaldo Contreras

A scalable MNase-seq framework for reproducible nucleosome profiling across pluripotent stem cell and cardiomyocyte models

The paper develops a scalable MNase-seq workflow for reproducible nucleosome profiling across multiple cell types and models.

Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia

The paper develops a workflow for isolating and profiling adult teleost cardiac cells, revealing exercise-induced hypertrophy and hyperplasia and defining proteo-transcriptomic regulatory networks.

OpenEMMU: a versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics

OpenEMMU improves EdU staining efficiency, brightness, and multiplexing for DNA replication and cell cycle analysis using affordable, open-source reagents.

Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma

This study identifies de novo lipogenesis as a mechanism of gemcitabine resistance in PDAC and shows that targeting lipid synthesis enzymes enhances treatment efficacy.