Author

Dan Jane‐wit

Yale UniversityORCID 0000-0001-7115-0362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Andrea NansiD· 1 shared Clancy W. MullaniD· 1 shared Doryen BubeckiD· 1 shared Dylan P. NooneiD· 1 shared George TellidesiD· 1 shared Gilbert Moeckel· 1 shared Haitian Zhou· 1 shared J J JohnsoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrea NansORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 17, 2026

Internalized Components of Membrane Attack Complexes Disrupt Proteostasis and Acquire Alarmin-Like Properties

宋贵玉, Zihan Ma, Matthew Fan…·Dan Jane‐wit

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

2 citations

mouseproteomics

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