Author

Karen M. Dobos

Colorado State UniversityORCID 0000-0001-7115-8524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

David Michael LewinsohniD· 3 shared Carolina MehaffyiD· 2 shared Deborah A. LewinsohniD· 2 shared Digby Francis WarneriD· 2 shared Luisa María Nieto RamíreziD· 2 shared Mabule L. Raphela· 2 shared Megan Lucas· 2 shared Melissa Dalcina ChengalroyeniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

David Michael LewinsohnORCID

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3 papers

Recent·Most cited

ImmunologyJournal of Biological ChemistryPeer-reviewedFeb 26, 2026

Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens

Corinna A. Kulicke, Chance Lemon, Jason R. Krawic…·David Michael Lewinsohn

This study shows that mutations in MR1 outside the antigen binding groove differentially affect exogenous antigen presentation by altering B2M association.

4 citationstop 3%

humanproteomics

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ImmunologyPLoS PathogensPeer-reviewedJul 1, 2025

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Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists

Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley…·David Michael Lewinsohn

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

19 citationstop 1%

bacteria (other)human

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Molecular BiologyMicrobiology SpectrumPeer-reviewedJun 25, 2024

Modulation of riboflavin biosynthesis and utilization in mycobacteria

Melissa Dalcina Chengalroyen, Carolina Mehaffy, Megan Lucas…·Valerie Mizrahi

This study investigates riboflavin biosynthesis and utilization in mycobacteria by creating conditional knockdowns and analyzing their impact on viability and MAIT cell recognition.

17 citationstop 3%

humanexperimental assay

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