Author

Mabule L. Raphela

University of Cape Town

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Carolina MehaffyiD· 2 shared David Michael LewinsohniD· 2 shared Deborah A. LewinsohniD· 2 shared Digby Francis WarneriD· 2 shared Karen M. DobosiD· 2 shared Megan Lucas· 2 shared Melissa Dalcina ChengalroyeniD· 2 shared Nurudeen OketadeiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Carolina MehaffyORCID

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2 papers

Recent·Most cited

Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists

Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley, Megan Lucas, Luisa María Nieto Ramírez, Mabule L. Raphela, Gwendolyn M. Swarbrick, Paul S. Soma, Mandisa Zuma, Digby Francis Warner, Deborah A. Lewinsohn, Carolina Mehaffy, Erin J. Adams, William H. Hildebrand, Karen M. Dobos, , David Michael Lewinsohn

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

PLoS Pathogens · Jul 1, 2025Peer-reviewedImmunology✦ In-depth digest

Modulation of riboflavin biosynthesis and utilization in mycobacteria

Melissa Dalcina Chengalroyen, Carolina Mehaffy, Megan Lucas, Niel Bauer, Mabule L. Raphela, Nurudeen Oketade, Digby Francis Warner, Deborah A. Lewinsohn, David Michael Lewinsohn, Karen M. Dobos, Valerie Mizrahi

This study investigates riboflavin biosynthesis and utilization in mycobacteria by creating conditional knockdowns and analyzing their impact on viability and MAIT cell recognition.

Microbiology Spectrum · Jun 25, 2024Peer-reviewedMolecular Biology