Author

Carolina Mehaffy

Colorado State UniversityORCID 0000-0002-7634-5131Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David Michael LewinsohniD· 2 shared Deborah A. LewinsohniD· 2 shared Digby Francis WarneriD· 2 shared Karen M. DobosiD· 2 shared Mabule L. Raphela· 2 shared Megan Lucas· 2 shared Melissa Dalcina ChengalroyeniD· 2 shared Nurudeen OketadeiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

David Michael LewinsohnORCID

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Author profile →

3 papers

Recent·Most cited

Inflammatory Biomarkers of Asymptomatic and Symptomatic Tuberculosis

Denis Awany, Dominique T Ariefdien, Simon C. Mendelsohn, Virginie Rozot, Humphrey Mulenga, Sarah Nyangu, Michele D. Tameris, Tumelo Moloantoa, Austin Katona, Fernanda Maruri, Firdows Noor, Ravindre Panchia, Khuthadzo E. Hlongwane, Kim Stanley, Yuri F. van der Heijden, , Petrus Tyambetyuv

This study identifies transcriptomic and proteomic features of asymptomatic tuberculosis, revealing distinct sub-clusters and a new blood signature, but finds weaker diagnostic performance for asymptomatic cases compared to symptomatic ones.

Nature Communications · Jul 25, 2026Peer-reviewedImmunology

Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists

Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley, Megan Lucas, Luisa María Nieto Ramírez, Mabule L. Raphela, Gwendolyn M. Swarbrick, Paul S. Soma, Mandisa Zuma, Digby Francis Warner, Deborah A. Lewinsohn, Carolina Mehaffy, Erin J. Adams, William H. Hildebrand, Karen M. Dobos, , David Michael Lewinsohn

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

PLoS Pathogens · Jul 1, 2025Peer-reviewedImmunology✦ In-depth digest

Modulation of riboflavin biosynthesis and utilization in mycobacteria

Melissa Dalcina Chengalroyen, Carolina Mehaffy, Megan Lucas, Niel Bauer, Mabule L. Raphela, Nurudeen Oketade, Digby Francis Warner, Deborah A. Lewinsohn, David Michael Lewinsohn, Karen M. Dobos, Valerie Mizrahi

This study investigates riboflavin biosynthesis and utilization in mycobacteria by creating conditional knockdowns and analyzing their impact on viability and MAIT cell recognition.

Microbiology Spectrum · Jun 25, 2024Peer-reviewedMolecular Biology