Toru Takumi

The paper predicts post-pubertal social behavior variability in a mouse model of paternal 15q11-13 duplication using neonatal social communication and gene expression data.

This study identifies the thalamo-insular pathway as critical for tic generation in a mouse model of Tourette syndrome, showing that its inhibition reduces tic-like behaviors.

This study shows prucalopride improves GI transit and social behavior in a mouse model of Dup15q syndrome by targeting 5-HT4 receptors.

The paper investigates how neurons in the agranular insular cortex distinguish between familiar and novel social conspecifics using calcium imaging in mice during social recognition memory and discrimination tasks.

This study uses a CNN-RNN deep learning model to classify mouse behavioral states from cortex-wide calcium imaging data, identifying key somatosensory regions involved in behavior classification.

The paper identifies aberrant axon initial segment (AIS) structures in ASD model mice as indicators of altered task-independent neural activity.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

The paper identifies DRACC1 as a novel synaptic protein that facilitates PSD protein assembly through liquid-liquid phase separation by analyzing 35 PSD proteome datasets.

The paper uses VR-based real-time imaging to study cortical functional connectivity dynamics during behavioral transitions in a mouse model of autism, finding altered FC patterns in motor areas associated with motor clumsiness.

The paper investigates paraspeckle formation in naked mole-rats, finding that nNEAT1_2 recruits different RNA binding proteins compared to mice.

The paper examines changes in PSD protein composition across development in mice and primates, linking these changes to autism spectrum disorder.

The paper establishes genetically modified mouse embryonic stem cell lines for autism spectrum disorder research and uses single-cell RNA sequencing to identify cell-type and CNV-specific molecular features.

This study generates isogenic hES cell lines with reciprocal 1q21.1 CNVs and shows opposite differentiation outcomes and shared hyperexcitability features.

This study shows that hippocampal ripple-mediated replay transforms fragmented spatial codes into stable cortical contextual representations through experience-dependent synaptic remodeling.

The paper identifies two subsets of insular cortex neurons in mice that encode social exploration behavior differently during interactions with social targets.

This study maps the topography of serotonergic fibers in the mouse brain using transgenic mice, revealing new regional density and anatomical patterns.