Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation
Luca Peruzzotti‐Jametti, C.M. Willis, Regan Hamel, Grzegorz Krzak, Julie A. Reisz, Hiran A. Prag, Vin‐Cent Wu, Y. Xiang, Aletta M.R. van den Bosch, Alexandra M. Nicaise, L. Roth, Georgina R. Bates, H. Huang, Amy E. Vincent, Christian Frezza, , Stefano Pluchino
The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.
bioRxiv · Jan 3, 2024 · PreprintNeuroscience