Roger Cox

Mechanisms of the FTO locus association with obesity: Irx3 controls a sumoylation-dependent switch between adipogenesis and osteogenesis

This study identifies IRX3 as a regulator of sumoylation that controls adipogenesis and osteogenesis through epigenetic mechanisms, linking the FTO locus to obesity.

TBX15 regulates a network of immune response genes in adipose tissue and alters fat mass and depot weight in heterozygous knockout mice

Loss of RREB1 reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks

The paper introduces DeepCytometer, a deep learning pipeline for segmenting whole slides of mouse white adipose tissue, and uses it to analyze phenotypes in Klf14 mouse models.