Varsha Rajesh

Out-of-the-box bioinformatics capabilities of large language models (LLMs)

This study evaluates the performance of three large language models on basic bioinformatics tasks compared to human performance, finding LLMs match human accuracy in some areas but struggle with complex tasks like sequence alignment.

Heterogeneous endocrine cell composition defines human islet functional phenotypes

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

Loss of RREB1 reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

HumanIslets: An integrated platform for human islet data access and analysis

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk

A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.