Xu Zhao

Mechanisms of the FTO locus association with obesity: Irx3 controls a sumoylation-dependent switch between adipogenesis and osteogenesis

This study identifies IRX3 as a regulator of sumoylation that controls adipogenesis and osteogenesis through epigenetic mechanisms, linking the FTO locus to obesity.

Pharmacological Inhibition of SUMOylation with TAK-981 Mimics Genetic HypoSUMOylation in Murine Perigonadal White Adipose Tissue

This study shows that inhibiting SUMOylation with TAK-981 in mice reduces adipose tissue weight and adipocyte size, mimicking genetic hypoSUMOylation effects.

Mitotic chromosome condensation resets chromatin to maintain transcriptional homeostasis

The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.

Waves of sumoylation support transcription dynamics during adipocyte differentiation

This study identifies the dual role of sumoylation in adipocyte differentiation by regulating gene expression and transcriptional network rewiring through SLAMseq and ChIPseq.