Pierre Chymkowitch

The paper shows that transient SUMOylation inhibition in human pre-adipocytes leads to stable beige differentiation when combined with PPARG activation.

This study identifies IRX3 as a regulator of sumoylation that controls adipogenesis and osteogenesis through epigenetic mechanisms, linking the FTO locus to obesity.

This study shows that inhibiting SUMOylation with TAK-981 in mice reduces adipose tissue weight and adipocyte size, mimicking genetic hypoSUMOylation effects.

The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.

This study identifies the dual role of sumoylation in adipocyte differentiation by regulating gene expression and transcriptional network rewiring through SLAMseq and ChIPseq.