Author

Xiangling Meng

Stanford MedicineORCID 0000-0002-3528-4037Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sergiu P. PașcaiD· 3 shared Fikri BireyiD· 2 shared Ji‐il KimiD· 2 shared John R. HuguenardiD· 2 shared Mayuri Vijay TheteiD· 2 shared Noah ReisiD· 2 shared Anca M. PașcaiD· 1 shared Arpana Arjun McKinney· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Sergiu P. PașcaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Human neuromodulatory assembloids to study serotonin signaling and disease

Sabina Kanton, Xiangling Meng, Chunyang Dong, Fikri Birey, Dong Wang, Noah Reis, Se‐Jin Yoon, Ji‐il Kim, James P. McQueen, Noriaki Sakai, Seiji Nishino, John R. Huguenard, Sergiu P. Pașca

This study creates human neuromodulatory assembloids to investigate serotonin signaling and disease mechanisms, showing altered 5-HT dynamics in 22q11.2DS and rescue with SSRIs.

bioRxiv · Mar 10, 2026 · PreprintNeuroscience

CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development

Xiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos, Michael Cory Bassik, Sergiu P. Pașca

The paper uses CRISPR screens in human forebrain assembloids to identify NDD genes involved in interneuron generation and migration, revealing novel roles for the ER in migration.

Nature · Sep 27, 2023Peer-reviewedNeuroscience

Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway

Ji‐il Kim, Yuki Miura, Min-Yin Li, Omer Revah, Sridhar Selvaraj, Fikri Birey, Xiangling Meng, Mayuri Vijay Thete, Sergey D. Pavlov, Jimena Andersen, Anca M. Pașca, Matthew Hebden Porteus, John R. Huguenard, Sergiu P. Pașca

This study uses human assembloids to investigate how CACNA1G gene variants affect thalamocortical pathway function in neuropsychiatric disorders.

bioRxiv · Mar 15, 2023 · PreprintNeuroscience