Venkata P. Dandey

VitriFlex is an open-source robotic platform for cryo-EM grid preparation that enables customizable and high-resolution grid production through modular design and programmable control.

The paper identifies a ternary PUF complex in C. elegans that regulates germline stem cells by repressing and activating gld-1 mRNA through adjacent FBEs.

This study uses time-resolved cryo-EM to visualize early intermediates in bacterial RNA polymerase promoter melting, revealing key steps in the formation of the transcription-competent open complex.

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

The paper reduces particle adsorption to air-water interfaces in cryoEM using Spotiton robot and nanowire grids, demonstrated on three biological samples.

The paper describes new features and applications of Spotiton, a cryoEM sample vitrification instrument, showing it produces high-quality specimens with no apparent sample damage.