Alternative pathway androgen biosynthesis and human fetal female virilization
Nicole Reisch, ANGELA E. R. TAYLOR, Edson F. Nogueira, Daniel J. Asby, Vivek Dhir, Andrew A. Berry, Nils Peter Krone, Richard Joseph Auchus, C.H.L. Shackleton, Neil A. Hanley, Wiebke Arlt
The paper demonstrates an alternative androgen biosynthesis pathway in human fetal females with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency, leading to virilization despite low circulating androgens.
Proceedings of the National Academy of Sciences · Oct 14, 2019Peer-reviewedDevelopmental Biology