Lizhong Liu

The paper identifies a new rostral midline progenitor population in human embryos using spatial transcriptomics and shows their role in mesoendoderm induction.

This study establishes co-cultures of embryonic and extraembryonic stem cells to study lineage crosstalk during early mammalian development, revealing growth inhibition of pluripotent cells by extraembryonic endoderm cells.

This paper develops an optimized protocol for large-scale production of human blastoids and identifies signaling pathways and endometrial stromal effects in blastocyst development.

The paper develops a method to generate bovine blastocyst-like structures (blastoids) from stem cells, which mimic blastocysts in morphology and transcriptomes.

The paper shows Nodal is a short-range morphogen in human gastruloids, spreading via a relay mechanism and regulated by Lefty.

The paper shows BMP signaling initiates WNT, which initiates NODAL in human gastruloids, revealing dynamic signaling waves that mediate epiblast patterning without a signaling gradient.

coMethDMR identifies differentially methylated regions by first selecting co-methylated sub-regions and then testing their association with phenotypes using a mixed effects model.

pathwayPCA is an R package that performs integrative pathway analysis with modern PCA methods and gene selection, enabling multi-omics data analysis and sample-specific pathway activity estimation.