Nicholas R. Klug

This study investigates how GqPCR activity regulates detrusor smooth muscle phasic contractions and transient pressure events through effects on Ca2+ activity and membrane potential.

The paper identifies artery-like smooth muscle cells in dural venous sinuses that actively regulate venous outflow through contractile function and calcium signaling.

This study develops a mathematical model of cerebral mural cell electrophysiology and biomechanics to understand myogenic responses in arterioles and capillaries, revealing how Ca2+ dynamics and ion channel activity influence vascular resistance.

This study shows adenosine and low oxygen reduce bladder contractility via A2B receptors and BKCa channels in mice.

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.