Nidia Quillinan

Single Cell Cytometry of Mouse Brain Tissue

This study compares methods for generating single-cell suspensions from mouse brain tissue using mass cytometry, finding that mechanical dissociation with enzymes yields viable cells while Percoll reduces viability, and cryopreservation preserves cell composition.

Novel neonatal hypoxic-ischemic model demonstrates neuroinflammation-associated memory deficits without neuronal loss

This paper introduces a novel rodent model of neonatal global cerebral ischemia using cardiac arrest and cardiopulmonary resuscitation, showing memory deficits without neuronal loss.

Harnessing micrometer-scale tPA beads for high plasmin flux and accelerated fibrinolysis

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

Oxygen/glucose-deprivation causes long-term impairment of synaptic CaMKII movement

This study shows that oxygen/glucose-deprivation impairs CaMKII movement in hippocampal neurons, and inhibiting CaMKII prevents this impairment, linking it to LTP and ischemia.

Enhanced Calcium Signaling in BLA Pyramidal Neurons Underlies a Sex and Circuit Specific Amygdala Dysfunction After Global Cerebral Ischemia

This study identifies sex- and circuit-specific amygdala dysfunction after global cerebral ischemia in mice, linked to enhanced calcium signaling in male survivors.

Endogenous recovery of hippocampal function following global cerebral ischemia in juvenile female mice is influenced by neuroinflammation and circulating sex hormones.

This study shows that endogenous recovery of hippocampal long-term potentiation (LTP) after global cerebral ischemia in juvenile female mice depends on neuroinflammation and sex hormones, differing from males and adults.

TRPM2-CaMKII signaling drives excessive GABAergic synaptic inhibition following ischemia

The paper shows that TRPM2-CaMKII signaling enhances GABAergic synaptic inhibition after ischemia, leading to E/I imbalance and potential therapeutic targets for cognitive recovery.

Distinct excitability of thalamocortical neurons correlates with the presence of cerebellar afferents

The paper shows that thalamocortical neurons with cerebellar afferents have distinct firing properties compared to those with basal ganglia afferents.

Chronic Changes In Oligodendrocyte Sub-Populations After Middle Cerebral Artery Occlusion in Neonatal Mice.

This study uses scRNA-seq to analyze oligodendrocyte gene expression changes in a neonatal mouse model of stroke, identifying a reactive subset that may be a target for white matter repair.

Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents

This study shows that short-term CaMKII inhibition with tatCN19o does not erase existing memories and is neuroprotective in non-rodents.