Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation
Chika Mochizuki-Ono, Yoshitaka Taketomi, Atsushi Irie, Kuniyuki Kano, Yuki Nagasaki, Yoshimi Miki, Takashi Ono, Yasumasa Nishito, Takahiro Nakajima, Yuri Tomabechi, Kazuharu Hanada, Mikako Shirouzu, Takashi Watanabe, Kosuke Hata, Yoshihiro Izumi, , Makoto Murakami
This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.
Cell Reports · Jun 1, 2026Peer-reviewedImmunology