Author

Makoto Murakami

Center for Disease Biology and Integrative Medicine, The University of TokyoORCID 0000-0002-4565-6017Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Makoto Murakami1 paper · Konan University

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Immunology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Yoshitaka TaketomiiD· 3 shared Yuki NagasakiiD· 2 shared Ai KotaniiD· 1 shared Akihiko MiyauchiiD· 1 shared Amar SahayiD· 1 shared Annarita ScardamagliaiD· 1 shared Anne‐Sophie Denommé‐PichoniD· 1 shared Antoine CivitiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Yoshitaka TaketomiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation

Chika Mochizuki-Ono, Yoshitaka Taketomi, Atsushi Irie, Kuniyuki Kano, Yuki Nagasaki, Yoshimi Miki, Takashi Ono, Yasumasa Nishito, Takahiro Nakajima, Yuri Tomabechi, Kazuharu Hanada, Mikako Shirouzu, Takashi Watanabe, Kosuke Hata, Yoshihiro Izumi, , Makoto Murakami

This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.

Cell Reports · Jun 1, 2026Peer-reviewedImmunology

Lysyl-phosphatidylglycerol promotes cell-to-cell interaction and biofilm formation of Staphylococcus aureus as a biofilm matrix component

Shinya Sugimoto, Koichiro Hara, Yoshitaka Taketomi, Yuki Nagasaki, Chikara Sato, Makoto Murakami, Yuki Kinjo

This study identifies lysyl-phosphatidylglycerol (Lys-PG) as a critical biofilm matrix component in Staphylococcus aureus that promotes cell-to-cell interactions and biofilm formation.

bioRxiv · Feb 19, 2025 · PreprintMicrobiology

An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience

Cinzia Vicidomini, Travis D. Goode, Kathleen M. McAvoy, Ruilin Yu, Conor H. Beveridge, Sanjay N. Iyer, Matheus B. Victor, Noelle Leary, Liam Evans, Michael J. Steinbaugh, Zon Weng Lai, Marina C. Lyon, Manuel Rico F.S Silvestre, Gracia M. Bonilla, Ruslan I. Sadreyev, , Amar Sahay

This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.

bioRxiv · Jul 26, 2024 · PreprintNeuroscience

Biallelic null variants in PNPLA8 cause microcephaly through the reduced abundance of basal radial glia

Yuji Nakamura, Issei S. Shimada, Reza Maroofian, Henry Houlden, Micol Falabella, Masanori Fujimoto, Emi Sato, Hiroshi Takase, Shiho Aoki, Akihiko Miyauchi, Eriko Koshimizu, Satoko Miyatake, Yuko Arioka, Mizuki Honda, Takayoshi Higashi, , Shinji Saitoh

This study identifies biallelic PNPLA8 variants causing microcephaly by reducing basal radial glia in cerebral organoids and disrupting phospholipid metabolism.

medRxiv · Apr 26, 2023 · PreprintGenetic & Genomic Medicine