Ken‐ichiro Hayashi

BRCA2 loss triggers a downward spiral of genomic instability via ROS-dependent metabolic collapse

This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.

A single-chain antibody-based AID2 system for conditional degradation of GFP-tagged and untagged proteins

This paper develops a scAb-AID2 system for conditional protein degradation without requiring degron tags, demonstrating its effectiveness in human and C. elegans cells.

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

Development of bright fluorescent auxin

This study develops a fluorescent auxin probe, BODIPY-IAA2, which visualizes auxin distribution in plants without activating auxin signaling.

Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns

The paper combines AID2 and BromoTag degron systems to enhance protein depletion, demonstrating their effectiveness in suppressing DNA replication by co-depleting ORC1 and CDC6.

Radicle growth regulation of root parasitic plants by auxin-related compounds

This study investigates auxin's role in radicle growth of root parasitic plants and shows that auxin manipulation can inhibit their growth.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5

This study identifies mitochondrial dysfunction in sporadic inclusion body myositis and shows that MA-5 improves mitochondrial function and protects myoblasts.