Author

Sara A. Martinez

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-4389-5604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Philip L. LorenziiD· 3 shared Bao Quoc TraniD· 2 shared Iqbal MahmudiD· 2 shared John N. WeinsteiniD· 2 shared Lin TaniD· 2 shared Alena I. DorofeevaiD· 1 shared Alvina I. KhamidullinaiD· 1 shared An Q DinhiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Philip L. LorenziORCID

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3 papers

Recent·Most cited

The ASNS inhibitor ASX-173 potentiates L-asparaginase anticancer activity

Victor Vyacheslavovich Tatarskiy, Wai-Kin Chan, Lin Tan, Alvina I. Khamidullina, Iqbal Mahmud, Shwetha V. Kumar, Julia Nuzhina, Sara A. Martinez, Bao Quoc Tran, Anna Skwarska, Nataliya G Pavlenko, Alena I. Dorofeeva, Marina Konopleva, Dmitry V. Genis, John N. Weinstein, , Philip L. Lorenzi

The paper identifies ASX-173 as a potent ASNS inhibitor that enhances the anti-cancer effects of L-asparaginase in leukemia and shows its potential across multiple cancer types.

bioRxiv · Jul 3, 2025 · PreprintCancer Biology

Ultra-Fast Multi-Organ Proteomics Unveils Tissue-Specific Mechanisms of Drug Efficacy and Toxicity

Yun Xiong, Lin Tan, Waikin Chan, Eric S. Yin, Sri Ramya Donepudi, Jibin Ding, Bo Wei, Bao Quoc Tran, Sara A. Martinez, Iqbal Mahmud, Hamish I. Stewart, Daniel J. Hermanson, John N. Weinstein, Philip L. Lorenzi

The paper introduces UFP-MS, a fast proteomics method, and applies it to study drug effects on mouse tissues, revealing tissue-specific metabolic changes.

bioRxiv · Sep 25, 2024 · PreprintSystems Biology

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

Shijie Liu, Seth T. Gammon, Lin Tan, Yaqi Gao, Kyoungmin Kim, Ian Williamson, Janet Pham, Angela Davidian, Radhika Khanna, Benjamin D. Gould, Rebecca Salazar, Heidi Vitrac, An Q Dinh, Evan C. Lien, Francisca N. de Luna Vitorino, , Anja Karlstaedt

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

bioRxiv · Jun 21, 2024 · PreprintMolecular Biology