Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila
Kyra Kerkhofs, Jyoti Garg, Étienne Fafard-Couture, Sherif Abou Elela, Michelle S. Scott, Ronald E. Pearlman, Mark A. Bayfield
The paper shows that Tetrahymena thermophila's Mlp1, lacking the RRM1 domain, functions as a La protein and alters tRNA processing by stabilizing 3-trailers and preventing leader/trailer pairing.
Nature Communications · Nov 28, 2022Peer-reviewedMolecular Biology