Mark A. Bayfield

Endonuclease G governs an antiviral RNA surveillance system in budding yeast

This study identifies Nuc1, a mitochondrial enzyme, as a regulator of an RNA surveillance system in yeast that limits replication of the L-A mycovirus.

Respiratory Syncytial Virus (RSV) optimizes the translational landscape during infection

This study shows RSV optimizes translational efficiency by increasing polysome formation and enhancing ribosome recruitment to AU-rich host and viral transcripts through the M2-1 protein.

SnoBIRD: A tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes

SnoBIRD identifies and refines C/D box snoRNA annotations across eukaryotes by distinguishing expressed snoRNAs from pseudogenes.

Crosstalk between the tRNA methyltransferase Trm1 and RNA chaperone La influences eukaryotic tRNA maturation

This study shows that the tRNA methyltransferase Trm1 can promote tRNA functionality without catalytic activity and interacts with La to influence tRNA modification.

The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA

This study shows that Bmc1 and Pof8 promote 2'-O-methylation of U6 snRNA and identify a non-canonical snoRNA guiding this modification.

Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila

The paper shows that Tetrahymena thermophila's Mlp1, lacking the RRM1 domain, functions as a La protein and alters tRNA processing by stabilizing 3-trailers and preventing leader/trailer pairing.

The methyl phosphate capping enzyme Bin3 is a stable component of the fission yeast telomerase holoenzyme

This study identifies Bin3 as a stable component of the fission yeast telomerase holoenzyme, showing its role in holoenzyme assembly through interactions with Pof8 and TER1.