Cryo-EM structure of DNA-unbound human MCM2-7 complex reveals new disease-relevant regulation
Yusong Liu, Mengquan Yang, Ping Lü, Haishan Gao, Maozhou He, Yitao Wang, Ao Qi, Ting Cao, Qiuqin Zhang, Shutao Qi, Yigong Shi, Hongtao Yu
The paper reveals a safety latch mechanism in the DNA-unbound MCM2-7 complex that blocks DNA entry and can be disrupted by mutations, leading to replication defects and DNA damage.
bioRxiv · May 31, 2025 · PreprintBiophysics