Sandra F. Gallego

The paper identifies synaptic dysfunction in cholinergic projection neurons as an early indicator of Parkinsonism across multiple fly models and links it to olfactory dysfunction and dopaminergic decline.

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

The paper shows that genetic susceptibility to DYT-TOR1A dystonia in mice depends on developmental lipid metabolic stress, which is influenced by sex and maternal diet.

The paper shows that inhibiting Lipin lipid phosphatase activity rescues neurological symptoms in TorsinA disease models.