Carles Calatayud

This study identifies Rab39 as a regulator of autophagy at presynaptic terminals in Drosophila, showing its role in trafficking Atg9 vesicles and its link to neurodegeneration.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

The paper identifies synaptic dysfunction in cholinergic projection neurons as an early indicator of Parkinsonism across multiple fly models and links it to olfactory dysfunction and dopaminergic decline.

The paper identifies molecular signatures of neuronal vulnerability to α-synuclein and tau toxicity, showing differential susceptibility independent of expression levels.

This study uses iPSC-derived dopaminergic neurons to model THD, showing disease-specific phenotypes and treatment responses.

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.