Katlijn Vints

Human Myelin Spheres for In Vitro Oligodendrocyte Maturation, Myelination and Neurological Disease Modeling

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

Presynaptic Release Probability Determines the Need for Sleep

The paper shows that presynaptic release probability, not synaptic strength, decreases with sleep loss and affects sleep need across species.

Neuronal autophagosomes are transported to astrocytes for degradation

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

Species-specific mitochondria dynamics and metabolism regulate the timing of neuronal development

This study shows that slower mitochondrial development and lower metabolic activity in human cortical neurons compared to mice delay neuronal maturation, and stimulating mitochondria accelerates this process.

Corticotropin-Releasing Factor Induces Functional And Structural Synaptic Remodelling In Acute Stress

This study shows CRF rapidly alters synaptic function and structure in hippocampal CA1 neurons during acute stress, enhancing synaptic communication and memory consolidation.