Jan C. M. van Hest

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

This study demonstrates DNA origami nanostructures that use enzymes to enhance mucosal diffusion, showing improved mobility in mucus through controlled enzyme placement.

This study investigates how DNA origami nanoparticle shape and ligand patterning affect diffusion in intestinal mucus, finding that topology-specific optimization is crucial for mucus penetration.

This study investigates how the fusion of biomolecular condensates, influenced by ageing and mixing rates, leads to the formation of multiphase structures with distinct material properties.