Author

Xian Shen

First Affiliated Hospital of Wenzhou Medical UniversityORCID 0000-0001-7974-830XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Althaf Shaik· 1 shared Bo-Xin Zhang· 1 shared Chen Ling· 1 shared Haibing ZhangiD· 1 shared Haixia ZhouiD· 1 shared Huan-Feng Ye· 1 shared Huipeng JiaoiD· 1 shared Jia Huang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Althaf Shaik

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity

Zhang-Hua Yang, Bo-Xin Zhang, Huan-Feng Ye, Liang Shi, Rui Gong, Zhiyu Cai, Qiang Chen, Lei Wu, Jia Huang, Le Zhang, Huipeng Jiao, Pinglong Xu, Qinjie Weng, Jie Zhang, Jinheng Pan, , Wei Mo

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

Vita · Jan 1, 2026Peer-reviewedCell Biology

The TONSL-MMS22L complex and FANCM form an interdependent complex on chromatin to counter replication stress

Haixia Zhou, Jiaoyan Yan, Xinlei Cao, Jingfei Zhan, Chen Ling, Yunhui Luo, Zhuang Ma, Yingying Sun, Peining Song, Weiwei Liu, Lizhu Wang, Jiahuan Li, Althaf Shaik, Marina A. Bellani, Linqian Wang, , Zhijiang Yan

This paper shows that the TONSL-MMS22L complex and FANCM form an interdependent chromatin complex to resolve replication stress and improve cancer prognosis.

bioRxiv · Mar 7, 2025 · PreprintCell Biology