Paul F. Lambert

This paper shows E2 activates the DNA damage response by displacing CIP2A from TOPBP1, promoting viral replication and cell proliferation through ATM activation and ATR inhibition.

This study shows human APOBEC3B does not restrict murine papillomavirus MmuPV1 replication in cellulo or in vivo, suggesting papillomaviruses have evolved mechanisms to evade this antiviral factor.

This study identifies context-dependent myeloid-T cell interactions in HNSCC ICB response using integrated single-cell and spatial omics data.

This study shows that invasive cancer can develop and regress within weeks after papillomavirus infection in mice, highlighting the rapid progression and immune dependence of tumor regression.

This paper shows that the MmuPV1 E7 protein binds RB1 without using the canonical LXCXE motif and that this interaction is essential for papilloma formation in mice.

The paper shows that MST1R/RON and EGFR form a complex with syndecans that prevents p38MAPK activation, sustaining S-phase progression in carcinoma cells by inhibiting DNA replication stress.

This study investigates the role of IQGAP1 in head and neck squamous cell carcinoma by showing its necessity for PI3K/AKT signaling and carcinogenesis.