Richard James Mair

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

The paper identifies a spatiotemporal cancer cell trajectory in glioblastoma that explains tumor heterogeneity across regions and subclones.

This study uses single-cell multiomics to identify regulatory programs and plasticity regulators in glioblastoma, revealing MYT1L as a key repressor of malignant plasticity.

The paper profiles gene expression in human microglia from 141 patients, identifies population shifts in acute brain injury, maps eQTLs, and fine-maps Alzheimer's risk variants using hIPSC-derived macrophages.

The paper detects circulating tumor DNA in plasma and urine of glioma patients using sequencing guided by tumor mutations.

The paper shows that selecting short DNA fragments in plasma improves the detection of circulating tumour DNA by enriching mutated DNA, enabling identification of copy number alterations previously undetected.