Yuki Tsukada

Centrosome-centromere capture range, rather than centrosome arrangement, determines multipolar chromosome segregation pattern after whole-genome duplication

Profiling cell proliferation after whole-genome duplication in human cells

The paper uses live-imaging to study proliferation dynamics of post-WGD HCT116 cell lineages, finding that multipolar chromosome segregation limits proliferative capacity.

Sister chromatid separation determines the proliferative properties upon whole-genome duplication via homologous chromosome arrangement

This study shows that mitotic slippage and cytokinesis failure, two mechanisms of whole-genome duplication, differentially affect post-WGD cell viability through distinct chromosome segregation patterns.

An interplay between cytoplasmic flow and cell morphology during cytokinesis simulated by the moving-particle semi-implicit method

The paper simulates cytokinesis by modeling cytoplasmic flow and cortical elasticity interactions, showing spindle-driven flow creates a pressure minimum that initiates cleavage furrow formation.

Aberrant neuronal hyperactivation causes an age- and diet-dependent decline in associative learning behavior

This study shows that increased neuronal activity in aging C. elegans impairs associative learning behavior, which can be mitigated by dietary changes.

Genetic screens identified dual roles of MAST kinase and CREB within a single thermosensory neuron in the regulation of C. elegans thermotaxis behavior

Presynaptic MAST Kinase Controls Bidirectional Post-SynapticResponses to Convey Stimulus Valence in C. elegans

The paper shows that presynaptic MAST kinase in C. elegans controls bidirectional postsynaptic responses to encode thermal stimulus valence through opposing signals.

Identification of Animal Behavioral Strategies by Inverse Reinforcement Learning

This paper develops an inverse reinforcement learning framework to identify animal behavioral strategies from time-series data, applied to C. elegans thermotaxis, revealing distinct strategies for fed and starved worms.