Géraldine Seydoux

This study uses single-molecule imaging in C. elegans embryos to show that P granules concentrate mRNAs but do not directly promote translation.

This study identifies that structured domains in PGL-3 drive phase separation through oligomerization and interaction with RGG motifs, independent of RNA.

The paper identifies tts-2 as a TDMD trigger that drives decay of the mir-35-42 miRNA family in C. elegans embryos through base pairing with their seed sequence.

The paper identifies germline P-bodies in C. elegans embryos that are essential for germ cell fate specification by regulating maternal mRNAs.

The paper shows that interfacial protein clusters stabilize biomolecular condensates by regulating their dynamics and structural integrity.

The paper shows that two parallel sRNA amplification loops in C. elegans mediate RNAi inheritance by targeting nascent and mature transcripts through distinct mechanisms.

The paper shows that P granules in C. elegans germ cells prevent RNA interference genes from being silenced by piRNAs, maintaining their expression.

The paper analyzes the material properties of P granules in vivo and ex vivo, finding a non-dynamic shell that stabilizes their liquid phase.

This paper describes a method for efficient precision genome editing using linear donor DNAs with ~35bp homology arms for synthesis-dependent strand annealing repair of Cas9-induced breaks.

The paper introduces MIP-MAP, a method to map temperature-sensitive mutations in C. elegans using molecular inversion probes, achieving high-resolution genetic mapping with high-throughput sequencing.