John Ross Teijaro

This study evaluates CMX990, a coronavirus Mpro inhibitor, showing broad antiviral activity against multiple coronaviruses and superior pharmacologic properties compared to existing inhibitors.

The paper analyzes tissue-resident immune responses in vaccinated individuals to show that antibody responses are driven by lymphoid tissue B and CD4 T cells, not blood.

This paper identifies a direct interaction between SLC15A4 and LAMTOR1 that is required for endolysosomal TLR-mediated mTOR signaling and inflammatory cytokine production.

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

This study develops a degrader for Siglec-7 and -9 to reshape the tumor microenvironment and enhance T cell anti-tumor immunity in murine models.

This paper creates a mouse model of pegivirus infection and investigates immune mechanisms of persistence and cross-species infection.