Author

Laura Helen Comley

Karolinska InstitutetORCID 0000-0001-8282-8909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Christoph SchweingruberiD· 2 shared Eva HedlundiD· 2 shared Jik NijsseniD· 2 shared Susanne NichterwitziD· 2 shared Abraham Acevedo‐ArozenaiD· 1 shared Helena StorvalliD· 1 shared Ilary AllodiiD· 1 shared Irene MeiiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Christoph SchweingruberORCID

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2 papers

Recent·Most cited

Reevaluating the Role of Beta2-Microglobulin: New Insights on Selective Vulnerability in ALS Pathology

Mélanie Lebœuf, Jik Nijssen, Laura Helen Comley, Julio Cesar Aguila Benitez, Irene Mei, Silvia Gómez Alcalde, Ramón A. Muñoz de Bustillo Alfaro, Vlad Radoi, Susanne Nichterwitz, Christoph Schweingruber, Abraham Acevedo‐Arozena, Eva Hedlund, Staffan Cullheim

This study investigates the role of beta2-microglobulin and HLA in motor neuron vulnerability in ALS, finding dynamic regulation but not major disease modification.

Acta Neuropathologica · May 29, 2026Peer-reviewedNeuroscience

LCM-seq reveals unique transcriptional adaption mechanisms of resistant neurons in spinal muscular atrophy

Susanne Nichterwitz, Jik Nijssen, Helena Storvall, Christoph Schweingruber, Laura Helen Comley, Ilary Allodi, Mirjam van der Lee, Qiaolin Deng, Rickard Sandberg, Eva Hedlund

This study uses LCM-seq to analyze transcriptional changes in SMA, identifying cell-type specific adaptations that explain resistance in ocular motor neurons.

Genome Research · Aug 20, 2020Peer-reviewedNeuroscience