Author

Susanne Nichterwitz

Stockholm UniversityORCID 0000-0002-9950-5003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 4 Approach:statistical model· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Eva HedlundiD· 3 shared Jik NijsseniD· 3 shared Christoph SchweingruberiD· 2 shared Irene MeiiD· 2 shared Laura Helen ComleyiD· 2 shared Mélanie LebœufiD· 2 shared Abraham Acevedo‐ArozenaiD· 1 shared Abril Morales· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Eva HedlundORCID

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Author profile →

4 papers

Recent·Most cited

Reevaluating the Role of Beta2-Microglobulin: New Insights on Selective Vulnerability in ALS Pathology

Mélanie Lebœuf, Jik Nijssen, Laura Helen Comley, Julio Cesar Aguila Benitez, Irene Mei, Silvia Gómez Alcalde, Ramón A. Muñoz de Bustillo Alfaro, Vlad Radoi, Susanne Nichterwitz, Christoph Schweingruber, Abraham Acevedo‐Arozena, Eva Hedlund, Staffan Cullheim

This study investigates the role of beta2-microglobulin and HLA in motor neuron vulnerability in ALS, finding dynamic regulation but not major disease modification.

Acta Neuropathologica · May 29, 2026Peer-reviewedNeuroscience

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex

Celine K. Vuong, Alexis Weber, Patrick Seong, Nana Matoba, Yu-Jen Chen, Jordan Peyer, Shahab Younesi, Angelo Salinda, Daniel Gomez, Gabriella Rivas, Abril Morales, Beck Shafie, Pan Zhang, Susanne Nichterwitz, Le Qi, , Luis de la Torre-Ubieta

This study uses single-nucleus multi-omics to analyze the developing Down syndrome neocortex, identifying dysregulated molecular and gene-regulatory mechanisms affecting neurogenesis and cell specification.

Science · Apr 23, 2026Peer-reviewedGenomics

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations

Irene Mei, Susanne Nichterwitz, Mélanie Lebœuf, Jik Nijssen, Isadora Lenoël, Dirk Repsilber, Christian S. Lobsiger, Eva Hedlund

The paper identifies gene expression patterns in motor neurons that predict ALS across species and SOD1 mutations, revealing differences in vulnerability and resilience.

bioRxiv · Mar 15, 2024Neuroscience

LCM-seq reveals unique transcriptional adaption mechanisms of resistant neurons in spinal muscular atrophy

Susanne Nichterwitz, Jik Nijssen, Helena Storvall, Christoph Schweingruber, Laura Helen Comley, Ilary Allodi, Mirjam van der Lee, Qiaolin Deng, Rickard Sandberg, Eva Hedlund

This study uses LCM-seq to analyze transcriptional changes in SMA, identifying cell-type specific adaptations that explain resistance in ocular motor neurons.

Genome Research · Aug 20, 2020Peer-reviewedNeuroscience