Xiao‐Jun Huang

This study identifies a small molecule that rescues NPM1c phase separation loss, restoring nucleolar localization and showing anti-leukemia activity in AML models.

This study shows that microglia replacement through bone marrow transplantation halts disease progression in both mouse models and human patients with ALSP.

The paper investigates chromatin compaction during erythropoiesis, finding that transcriptionally active regions are maintained while heterochromatin is compressed, and TAD boundaries are disrupted.

The paper identifies high-risk factors and actionable targets in T-ALL through integrated genomic and transcriptomic analyses of 165 patients, finding RAS pathway and PTEN mutations as poor survival factors and potential therapeutic targets.

This paper introduces an enrichment-free method to analyze native O-glycoproteomes, revealing high O-glycosylation in antibodies from autoimmune diseases.

The paper identifies 3D genome alterations and enhancer hijacking mechanisms in T-lineage acute lymphoblastic leukemia (T-ALL) using integrated analyses of 18 patients and 4 controls.

The paper characterizes 3D genome structure and chromatin accessibility in human tolerant T cells, identifying SOCS1 as a key regulator of tolerance.