Generation of Valvular Interstitial Cells from Human Pluripotent Stem Cells
Amine Mazine, Alexander A. Mikryukov, Ian Fernandes, Clifford Z. Liu, Soheil Jahangiri, Marcy Martin, Eric K. N. Gähwiler, Melanie Generali, Juliana Gomez, Neda Latifi, Yifei Miao, Yu Liu, Michael A Laflamme, Craig A. Simmons, Simon Philipp Hoerstrup, , Gordon M. Keller
This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.
Global Cardiology Science and Practice · Oct 6, 2025Peer-reviewedCell Biology