Dietmar Riedel

This paper shows that anle138b binds to a cavity in lipidic Aβ fibrils and reduces fibril formation by 75%, suggesting a potential therapeutic mechanism for Alzheimer's disease.

The paper shows Ups1 preferentially binds to positively curved membranes, facilitating phosphatidic acid transfer between mitochondrial membranes.

This study determines the molecular organisation of the human prohibitin complex within the mitochondrial inner membrane using structural biology methods.

The paper identifies molecular determinants enabling HIV capsid passage through NPCs by analyzing surface amino acid composition and FG repeat interactions.

This paper introduces REEL-EM, a method combining EELS and single-particle image processing to enable elemental mapping in cryo-preserved macromolecular complexes, demonstrating reliable localization of abundant elements.

The paper determines the structure of amyloid-β (Aβ40) fibrils bound to lipids using cryo-EM, showing lipid binding and potential relevance to Alzheimer's disease pathogenesis.

The paper identifies a mechanism involving ZP protein proteolysis that regulates membrane structure and tube integrity in Drosophila and humans, with implications for pulmonary diseases.

This study compares the release and effects of alpha-synuclein, Tau, and huntingtin in neuronal cells, showing similar release pathways and impacts on neuronal activity and inflammation.

The paper shows that a small population of synaptic vesicles contain different neurotransmitter transporters, enabling corelease of various neurotransmitter combinations.

The paper characterizes ectosomes and exosomes proteomes and shows they modulate neuronal activity differently.

The paper uses MINFLUX nanoscopy to visualize the molecular architecture of the photoreceptor active zone, revealing a serially duplicated complex of bassoon-RIM2-ubMunc13-2-CAST.

The paper identifies tight junctions as critical for germ plasm localization in zebrafish embryos, revealing a novel role for tight junction proteins in germ cell specification.