Ann M. Benz

A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABA A Receptor Agonism and NMDA Receptor Inhibition

This paper characterizes YX84, a novel neuroactive steroid with dual GABA A receptor agonism and NMDA receptor inhibition, showing favorable behavioral tolerability.

A role for δ subunit-containing GABA-A receptors on parvalbumin positive neurons in maintaining electrocortical signatures of sleep states

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

Multifaceted Actions of Neurosteroids

The paper investigates the range of actions of neurosteroid analogues using in silico and in vitro methods, revealing unexpected modulation of multiple targets beyond GABA-A receptors.

δ-containing GABAA receptors on parvalbumin interneurons modulate neuronal excitability and network dynamics in the mouse medial prefrontal cortex

This study shows that δ-containing GABAA receptors in PV interneurons regulate their excitability and inhibit pyramidal neurons in the mPFC, affecting network dynamics.

Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation

The paper examines how pharmacological manipulations affect the aperiodic exponent of EEG power spectra in mice, finding it is not a reliable marker of excitation/inhibition balance.