The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis
Isaac Kraz, Oi Wei Mak, Subray Hegde, Benjamin M. Lorton, Harrison Hector, Michael K. Broussalian, Sarah Graff, Jennifer T. Aguilan, J.B. Bonanno, Roozbeh Eskandari, Daniel Groom, Simone Sidoli, Steven C. Almo, Michael D. Brenowitz, Evripidis Gavathiotis, , David Shechter
This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.
bioRxiv · May 29, 2026 · PreprintBiochemistry