Intrinsic and extrinsic mechanisms alter neural cell fate specification in EPM1 Epilepsy
Andrea Forero, Veronica M. Pravatà, Fabrizia Pipicelli, Alessandro Soloperto, Francesco Di Matteo, Zagorka Bekjarova, Elisa Frenna, Laura Canafoglia, Francesca Ragona, Giuseppina Maccarrone, Mariano Gonzalez Pisfil, Christian Whal-Schott, Filippo M. Cernilogar, Matthias Eder, Rossella Di Giaimo, Silvia Cappello
This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.
bioRxiv · Nov 20, 2024 · PreprintNeuroscience