Matthias Eder

Intrinsic and extrinsic mechanisms alter neural cell fate specification in EPM1 Epilepsy

This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.

Neuronal Hyperactivity in Neurons Derived from Individuals with Grey Matter Heterotopia

This study investigates neuronal hyperactivity in human cerebral organoids derived from individuals with grey matter heterotopia, identifying functional and structural changes linked to the condition.

Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairment

This study identifies alternative polyadenylation (APA) as a molecular mechanism linking polygenic risk for schizophrenia to synaptic impairments through functional analysis in induced neurons.

Tripartite extended amygdala - basal ganglia CRH circuit drives arousal and avoidance behaviour

The paper identifies a novel tripartite CRH circuit connecting extended amygdala and basal ganglia that drives arousal and avoidance behaviour through CRH receptor 1 in the substantia nigra.

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

The role of m6A-RNA methylation in stress response regulation

This paper investigates how m6A RNA methylation in the brain is regulated by stress and shows its role in fear memory, transcriptome response, and synaptic plasticity, with implications for stress-related disorders.