Author

Giuseppina Maccarrone

Max Planck Institute of Psychiatry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Francesco Di MatteoiD· 3 shared Rossella Di GiaimoiD· 3 shared Silvia CappelloiD· 3 shared Andrea ForeroiD· 2 shared Fabrizia PipicelliiD· 2 shared Filippo M. CernilogariD· 2 shared Laura CanafogliaiD· 2 shared Mariano Gonzalez PisfiliD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Francesco Di MatteoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intrinsic and extrinsic mechanisms alter neural cell fate specification in EPM1 Epilepsy

Andrea Forero, Veronica M. Pravatà, Fabrizia Pipicelli, Alessandro Soloperto, Francesco Di Matteo, Zagorka Bekjarova, Elisa Frenna, Laura Canafoglia, Francesca Ragona, Giuseppina Maccarrone, Mariano Gonzalez Pisfil, Christian Whal-Schott, Filippo M. Cernilogar, Matthias Eder, Rossella Di Giaimo, Silvia Cappello

This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.

bioRxiv · Nov 20, 2024 · PreprintNeuroscience

Neuronal Hyperactivity in Neurons Derived from Individuals with Grey Matter Heterotopia

Francesco Di Matteo, Rebecca Bonrath, Hanna Schmidt, Ane Cristina Ayo Martin, Veronica M. Pravatà, Rossella Di Giaimo, Danusa Menegaz, Stephan Riesenberg, Femke M. S. de Vrij, Giuseppina Maccarrone, Maria Holzapfel, Tobias Straub, Steven A. Kushner, Stephen P. Robertson, Matthias Eder, Silvia Cappello

This study investigates neuronal hyperactivity in human cerebral organoids derived from individuals with grey matter heterotopia, identifying functional and structural changes linked to the condition.

bioRxiv · Jul 10, 2024 · PreprintNeuroscience

Extracellular vesicle-mediated trafficking of developmental cues is altered during human brain disease

Fabrizia Pipicelli, Andrea Forero, Sylvain Moser, Francesco Di Matteo, Natalia Baumann, Christian Grätz, Mariano Gonzalez Pisfil, Zagorka Bekjarova, Michael Walter Pfaffl, Laura Canafoglia, Benno Pütz, Pavel Kielkowski, Filippo M. Cernilogar, Giuseppina Maccarrone, Denis Jabaudon, , Silvia Cappello

The paper investigates how extracellular vesicles (EVs) mediate developmental cues during brain development and disease, finding altered EV composition and function in neurodevelopmental disorders.

bioRxiv · Jun 27, 2023 · PreprintDevelopmental Biology

Stress-primed secretory autophagy drives extracellular BDNF maturation

Silvia Martinelli, Elmira A. Anderzhanova, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Thomas Bajaj, Jakob Hartmann, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Giuseppina Maccarrone, Felix Hausch, Christoph W. Turck, Alexandra Philipsen, Mathias V. Schmidt, , Nils C. Gassen

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

bioRxiv · May 13, 2020 · PreprintMolecular Biology