Author

Alessandro Soloperto

Italian Institute of TechnologyORCID 0000-0002-8142-6059Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alessandro RosaiD· 1 shared Andrea ForeroiD· 1 shared Angelo M. ReggianiiD· 1 shared Carlo BrighiiD· 1 shared Chiara D’AntoniiD· 1 shared Christian Whal-Schott· 1 shared Elisa FrennaiD· 1 shared Fabrizia PipicelliiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alessandro RosaORCID

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2 papers

Recent·Most cited

Intrinsic and extrinsic mechanisms alter neural cell fate specification in EPM1 Epilepsy

Andrea Forero, Veronica M. Pravatà, Fabrizia Pipicelli, Alessandro Soloperto, Francesco Di Matteo, Zagorka Bekjarova, Elisa Frenna, Laura Canafoglia, Francesca Ragona, Giuseppina Maccarrone, Mariano Gonzalez Pisfil, Christian Whal-Schott, Filippo M. Cernilogar, Matthias Eder, Rossella Di Giaimo, Silvia Cappello

This study uses cerebral organoids to show that EPM1 mutations disrupt neural cell fate specification through intrinsic and extrinsic mechanisms involving EVs and SHH signaling.

bioRxiv · Nov 20, 2024 · PreprintNeuroscience

Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs

Carlo Brighi, Federico Salaris, Alessandro Soloperto, Federica Cordella, Silvia Ghirga, Valeria de Turris, Maria Rosito, Pier Francesca Porceddu, Chiara D’Antoni, Angelo M. Reggiani, Alessandro Rosa, Silvia Di Angelantonio

This study creates 2D and 3D human FXS models using FMRP-KO iPSCs, showing altered gene expression, impaired differentiation, and increased glial proliferation.

Cell Death and Disease · May 15, 2021Peer-reviewedNeuroscience